Risk Assessment of Transplanting Renal Allografts from HBcAb+ Donors etc

Transmission of hepatitis B virus infection through hepatitis B core antibody positive (HBcAb+) grafts to hepatitis B surface antigen negative (HBsAg- recipients has been reported (Liver Int. 2005 Dec;25(6):1169-74). The mandatory use of immunosupression in transplant patients favors reactivation of latent virus that may be present in grafts from HBsAg-negative anti-HBc-positive donors. With the persistent organ donor scarcity, the use of these grafts can not be avoided, specifically in urgent cases.

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