PTEN Knockout Prostate Cancer as a Model for Experimental Immunotherapy

The Journal of Urology (in press), 2009 –

Testing immunotherapeutic strategies for prostate cancer has been impeded by the lack of relevant tumor models in immunocompetent animals. This opportunity is now provided by the recent development of prostate specific PTEN knockout mice, which show spontaneous development of true adenocarcinoma arising from prostate epithelium and more faithfully recapitulate the human disease than previous model. Etc.

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