FUNDED GRANTS

Following are examples of grants that have been funded by the Mendez National Institute of Transplantation Foundation:

Principal Investigator: Joanna Schaenman, MD, PhD
Organization: The Regents of the University of California, San Francisco
Project Title: Immune Dysfunction in the Older Kidney Transplant Recipient
Awarded: February 2018
Amount of Award: $110,678



Principal Investigator:
 Sonja Schrepfer, MD, PhD
Co-Investigator: Tobias Deuse, MD; Alice Tarantal, PhD; Joseph Gold, PhD
Organization: The Regents of the University of California, San Francisco
Project Title: Genetic cellular engineering strategy to reduce allograft immunogenicity and enhance histocompatibility resulting in long-term graft function and survival
Awarded: February 2018
Amount of Award: $150,000



Principal Investigator:
 Phillip F. Halloran, MD, PhD
Co-Principal Investigator: Kieran M. Halloran, MD, PhD
Organization: Governors of the University of Alberta, Edmonton
Project Title: Molecular Diagnosis of Rejection Phenotypes in Lung Transplant Biopsies
Awarded: February 2018
Amount of Award: $100,000



Principal Investigator:
 Manikkam Suthanthiran, MD, FACP
Co-Investigator: Darshana Dadhania, MD; Thangamani Muthukumar, MD; Hua Yang, MD
Organization: Joan & Sanford I Weill Medical College of Cornell University
Project Title: Single-Cell RNA Sequencing of Urinary Cells for the Deconvolution of Human Kidney Allograft Rejection
Awarded: September 2017
Amount of Award: $50,000



Principal Investigator:
 Sarah E Gilpin, MD
Co-Investigator:  Harald C Ott, MD
Organization: Massachusetts General Hospital, Harvard Medical School
Project Title: Recreating the Developing Lung Microenvironment to Aid Tissue Repair and Regeneration
Awarded: September 2017
Amount of Award: $75,000



Principal Investigator:
 Jennifer C Lai, MD, MBA
Co-Investigator:  Sorry Segev, MD, PhD; Matthew Kappus, MD
Organization:  The Regents of the University of California on behalf of San Francisco Campus
Project Title: The Strength Training Intervention in Liver Transplantation (STRIVE-LT): A Multi-Center Pilot Randomized Clinical Trial
Awarded: September 2017
Amount of Award: $68,200



Principal Investigator:
Lindsey R. Bayden, MD
Co-Principle Investigator: Ann E. Woolley, MD, MPH
Organization: Brigham & Woman’s Hospital
Project Title: Transplanting Thoracic Organs from Hepatitis C Positive Donors to Hepatitis C Uninfected Recipients: Proof of Concept Trial
Awarded: March 2017
Amount of Award: $149,084 (24 months)



Principal Investigator:
Philip F. Halloran, MD, PhD
Co-Principle Investigator: Kieran M. Halloran, MD
Co-Investigator: Konrad S. Famulski, PhD, DSc
Organization: University of Alberta, Edmonton, Alberta, Canada
Project Title: Development of a molecular phenotyping system for biopsies from lung transplants
Awarded: November 2016
Amount of Award: $100,000



Principal Investigator:
James Cicciarelli, PhD
Co-Investigator: Nathan Lemp, PhD; & Noriyuki Kasahara, MD, PhD
Organization: Viracor-IBT Laboratories, Inc.
Project Title: HLA Class Monitoring II Matching Effect on Kidney Transplantation
Awarded: February 2016
Amount of Award: $22,500



Principal Investigator:
Manikkan Suthanthiran, MD, FACP
Co-Investigator: Darshana Dadhania, MD; Thangamani Muthukumar, MD; & John R. Lee, MD
Organization: Joan & Sanford I Weill Medical College of Cornell University
Project Title: Massively Parallel RNA Sequencing & Metabolamics: A Multiplatform Approach for the Discovery & Validation of Noninvasive Biomarkers of Kidney Allograft Status
Awarded: February 2016
Amount of Award: $50,000
Publication:
Nissaisorakarn, V., Human Immunology (2018), https:/doi.org/10.1016/j.humimm.2018.01.006



Principal Investigator:
Katrin Hacke, PhD
Co-Investigator: Noriyuki Kasahara, MD, PhD; James Cicciarelli, PhD; & Nathan Lemp,PhD
Organization: University of Miami
Project Title: Genome Editing of Stem Cells for In Vivo Chemoselection & Immunomodulation
Awarded: February 2016
Amount of Award: $74,999



Principal Investigator:
Maralyn Smith, PhD
Co-Investigator: Scott M. Cowden, MS; Gerald Morris, MD, PhD; Michelle L. Altrich, PhD; & Jeff D. Hester, PhD
Organization: Viracor-IBT Laboratories, Inc.
Project Title: Universal Noninvasive Detection of Solid Organ Transplant Rejection
Awarded: September 2015
Amount of Award: $50,000



Principal Investigator:
David Min, PharmD, FCCP, FASHP
Co-Investigator: Youngil Chang, PharmD
Organization: Western University of Health Sciences
Project Title: Glycosylation pattern as a novel diagnostic marker for antibody mediated rejection in kidney transplant patients
Awarded: September 2015
Amount of Award: $49,575



Principal Investigator:
Kentaro Kitano, MD, PhD
Co-Investigator: Harold Ott, MD
Organization: Massachusetts General Hospital – Harvard University
Project Title: Building transplantable intestine from patient derived cells
Awarded: September 2015
Amount of Award: $50,000
Publication: Kentaro Kitano et al. 2017 Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nature Communications 8:765DOI10.1038/S41467-017-00779-4



Principal Investigator:
Xi Ren, PhD.
Co-Investigator: Harold Ott, MD
Organization: Massachusetts General Hospital – Harvard University
Project Title: Inducing pulomonary microvascular specification from hiPSCs by resembling their native niche
Awarded: September 2015
Amount of Award: $50,000



Principal Investigator:
Mara McAdams DeMarco, PhD
Co-Investigator: Jeremy Watson, MD
Organization: Johns Hopkins University
Project Title: Prehabilitation for Adults with End-Stage Renal Disease on the Kidney Transplant Waitlist
Awarded: September 2015
Amount of Award: $50,000
Presented at:
Winter Symposium 2018
American Transplant Congress, Chicago, Il, 2017
Older Adult Independence Center Annual Meeting, Washington DC, 2017
Organ Donation and Transplantation Alliance Webinar Series, May 2018
Workgroup Member and Conference Participant, February 2018, Phoenix, AZ
Invited Symposium at American Society of Nephrology Kidney Week, New Orleans, LA
Invited Symposium at American Transplant Congress, April 2017, Chicago, IL



Principal Investigator:
Harry Prince, PhD
Co-Investigator:
Michelle Altrich, PhD
Organization:
Viracor-IBT, Laboratories, Inc.
Project Title:
Epidemiology of a new anthropod-transmitted virus: first assessment of Chikungunya virus (ChikV) prevalence among deceased organ and tissue donors
Awarded: 
September 2015
Amount of Award:
$23,000
Presented at: American Transplant Congress, June 2016
Publication:
Prince HE, ML Altrich, MJ Nowicki. 2016 Evaluation of two enzyme-linked immunosorbent assay kits for Chikungunya Virus IgM using samples from deceased organ and donor tissues. Clinical Vaccine Immunology 28:825-830



Principal Investigator:
Nicole Theodorpolous, MD
Co-Investigator: Michael G. Ison, MD, MS
Organization: The Ohio State University
Project Title: Screening Deceased Organ Donors for HIV, Hepatitis B and Hepatitis C Viruses with Nucleic Acid Testing
Awarded: February 2015
Amount of Award: $50,000
Presentations:
American Society of Transplantation, June 2018
International Congress of the Transplant Society, July 2018



Principal Investigator:
 Nikole Neidlinger, MD
Co-Investigator: Peter Chin-Hong, MD
Organization: California Transplant Donor Network
Project Title: Prevalence in Coccidiodomycosis in Population of Organ Donation at a Single Organ Procurement Organization
Awarded: February 2015
Amount of Award: $50,000
Presented at:
ID Week (multiple societies for experts in infectious diseases), October 2016
American Transplant Congress, May 2016
Publication:
American Journal of Transplantation. 2017; 17 (Suppl3)



Principal Investigator:
Marek Nowicki, PhD
Co-Principle Investigator: Michael Koss, MD
Co-Investigator: Youngil Chang, MD
Organization: Viracor-IBT Laboratories, Inc.
Project Title: Donors with isolated (“HBcAB only”) antibodies to HBV nucleocapsid seropositivity: true evidence for past exposure or laboratory artifacts?
Awarded: February 2015
Amount of Award: $21,529
Presented at:
American Transplant Congress, June 2016
American Association of Tissue Banks, 2016 – award for outstanding scientific abstract



Principal Investigator:
 James Cicciarelli, PhD
Co-Investigators: Nathan Lemp, PhD & Noriyuki Kasahara, MD, PhD
Organization: Viracor-IBT Laboratories, Inc.
Project Title: Improving the Identification of HLA Antibodies: The IgG Subclass Assay
Awarded: February 2015
Amount of Award: $25,120



Principal Investigators
:  Marek J Nowicki, Claudia Chinchilla-Reyes
Project Title: Increased Threat Of Vector-Borne West Nile Virus Infections Among Organ And Tissue Donors In Western United States
Amount of Award: $100,000
Published in:
1. Transplantation. 2014 May 15;97(9):881-9. Donor-derived West Nile virus infection in solid organ transplant recipients: report of four additional cases and review of clinical, diagnostic, and therapeutic features.
2. Emerg Infect Dis. 2013;19(9):1518-20. West Nile virus RNA in tissues from donor associated with transmission to organ transplant recipients.
Presented at:
American Transplant Congress, 2013
American Transplant Congress, 2010
World Transplant Congress, Berlin 2009



Principal Investigators
: Jennifer Unger, Nicole Mendez, Yasir Qazi
Project Title: Kidney Transplant Video Novela Project
Amount of Award: $80,000
Note: UniHealth Foundation awarded a grant of $599,887 and MNITF awarded an additional $80,000 to complete the Project
Published in:
Myriam Forster, Jon-Patrick Allem, Nicole Mendez, Yasir Qazi, and Jennifer B. Unger (2016) Evaluation of a telenovela designed to improve knowledge and behavioral intentions among Hispanic patients with end-stage renal disease in Southern California, Ethnicity & Health, 21:1, 58-70, DOI:10.1080/13557858.2015.1007119
Presented at:
National Kidney Foundation Spring Conference, Las Vegas 2014
ESRD Network of Texas Conference – Nephrology Today & Tomorrow 2014 (October 2014)



Principal Investigators
:  Marek J Nowicki, Claudia Chinchilla-Reyes
Project Title: Development and Implementation of Nucleic Acid Screening for HIV, HCV and HBV among organ and Tissue Donors in the United States.
Amount of Award: $150,000
Published in:
1. Am J Transplant. 2011 Jun;11(6):1201-8. Estimated risk of human immunodeficiency virus and hepatitis C virus infection among potential organ donors from 17 organ procurement organizations in the United States.
2. AIDS. 2011 Mar 13;25(5):619-23. Absence of reproducibly detectable low-level HIV viremia in highly exposed seronegative men and women.
Presented at:
Several international meetings including 2013 American Transplant Congress, 2014 World Transplant Congress and at 2014 ICAAC.



Principal Investigators
:  Marek J Nowicki, Claudia Chinchilla-Reyes
Project Title: HTLV-I/II screening for Organ and Tissue Donors
Amount of Award: $50,000
Transplantation. 2006 Nov 15;82(9):1210-3. High seroprevalence of anti-HTLV-I/II antibodies among solid organ donors necessitates confirmatory testing.
Published in:
1. Transplantation. 2006 Nov 15;82(9):1210-3. High seroprevalence of anti-HTLV-I/II antibodies among solid organ donors necessitates confirmatory testing.
2. Am J Transplant. 2010 Feb;10(2):207-13. Donor screening for human T-cell lymphotrophic virus 1/2: changing paradigms for changing testing capacity.
Presented at:
American Transplant Congress, 2012