The MDR1/ABCB1 Gene, a High-Impact Risk Factor for Cardiac Transplant Rejection

Transplantation. 82:1677-1682, 2006 –

Variations in the expression and activity levels of the multidrug-resistance MDR1/ABCB1 encoded glycoprotein (P-gp) have an impact on the therapeutic efficacy of many drugs. C3435T and G2677 polymorphisms of the MDR1/ABCB1 gene correlate with cellular expression levels of P-gp, a membrane-bound efflux pump which removes a multitude of drugs, including chemotherapy drugs and immunosuppressants, from cells. We aimed to investigate whether the phenomenon of drug resistance, mediated by the MDR1/ABCB1 gene and seen in tumor cells to chemotherapeutic agents, is important in the field of transplantation, predisposing some patients to resistance to immunosuppressants.

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