The Evaluation in vitro of Glucocorticoid Sensitivity in Transplant Patients

There is currently a lack of predictive methods to define glucocorticoid (GC) sensitivity, which is extremely variable among individuals. In particular, identifying patients in whom steroids will have immunosuppressive and toxic activities is important in transplantation. Therefore we have sought to establish an in vitro pharmacokinetic assay to investigate leukocyte proliferation and cytokine production, with the intention of applying such a test in transplantation.

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