Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis

Pediatr Allergy Immunol 17: 578-582, 2006 –

T lymphocytes accumulating in the skin of patients with atopic dermatitis (AD) have a prolonged survival and are key mediators of this inflammatory disease. The anti-apoptotic bfl-1 gene is unique in that it is the only member of the Bcl-2 family that is transcriptionally regulated by inflammatory cytokines and might therefore be important in promoting the survival of effector T cells in patients with AD. Etc.

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