IL-6 is a key pro-inflammatory cytokine unregulated after Brain Death (BD) in humans. It leads to adhesion molecule activation and leukocyte invasion in all organs. Pre-explantation organ dysfunction is a direct consequence of inflammation, and renders many organs unsuitable for transplantation. Functionally, IL-6 elevation correlates with deteriorating donor cardiac function in humans and its unregulation in kidney and liver donors worsens ischemia-reperfusion injury in recipients. Etc.