Association between de novo Donor Specific HLA Antibody, C4D staining in Renal Graft Biopsy and Graft Outcome

Despite improved early graft survival, long-term kidney graft loss rate has not been reduced. Both HLA antibodies and HLA donor specific antibodies (DSA) have been detected and may be causal in chronic allograft nephropathy (CAN) and, especially, in acute rejection. We evaluated the association between DSA, C4d staining in transplant and graft outcome.

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