RESEARCH ADVISORY BOARD

CLAUDIA CHINCILLA REYES_crClaudia Chinchilla-Reyes

Claudia Chinchilla-Reyes has been a member of the research team at the Mendez National Institute of Transplantation (MNIT) for more than 11 years. During her tenure, she’s worked on the validation and implementation of new cadaveric donor screening assays like HIV-1/HCV NAT, T. cruzi and West Nile Virus. In her management of every aspect of these studies, she has been involved in obtaining an Institutional Review Board (IRB) approval for each project; performing retrospective testing on stored cadaveric donor specimens; analyzing and preparing the data for presentations; presenting data to Organ Procurement Organization (OPO) and at conferences like the American Transplant Congress (ATC); and helping the Clinical Testing Laboratory implement the new assay into their testing panel. Together with the Donor Screening Clinical Testing Laboratory, her research aim has been to ensure the most up-to-date donor screening panel, through using the most sensitive assays available, and offering OPO clients the appropriate diagnostic assay for their donor population and demographics. Claudia is currently responsible for the Quality aspects of the Donor Screening and Histocompatibility Clinical Laboratories, ensuring that good quality processes are in place to deliver the fast turn-around-time needed for organ transplantation, along with reliable results to identify good quality organs.

JAMES CICCIARELLI_crJim Cicciarelli

James Cicciarelli, PhD is the director of several HLA labs in California, including the Viracor-IBT HLA Laboratory, the MNIT Immunogenetics Lab, Sharp Hospital, and BloodSource. He has more than 30 years of experience and holds several board certifications in histocompatibility and immunogenetics. He is also a Clinical Professor of Urology and Surgery at the USC Keck School of Medicine, and the author of over 100 scientific articles and 30 book chapter reviews. He serves on the Board of Advisors for OneLegacy and the Medical Advisory Committee for Sharp Hospital. Dr. Cicciarelli received his BS in Biology from Tulane University, his MS in Biology and Chemistry from Southern Illinois University Edwardsville, and his PhD in Immunology from Southern Illinois University Carbondale. His current research activities include IgG subclass specific assays, siRNA regulation of HLA genetic expression, and complement flow crossmatch deceased donor assay. Research interests include, Immunobiology of transplant rejection; Histocompatibility and transplant survival; HLA disease association and mechanism; Immunoregulatory role of HLA molecules; Antigenic determinants of HLA; Clinical diagnostic and prognostic tests for transplant recipients and/or candidates; and HLA Molecular typing and diagnostics using chip arrays.

NORI KASAHARA_crNori Kasahara

Dr. Noriyuki Kasahara graduated from Tokyo Medical & Dental University in 1986, and completed post-graduate clinical training and Board certification in Laboratory Medicine/Clinical Pathology at the University of California, San Francisco (UCSF), where he also obtained his PhD in 1994 from the Interdepartmental Program in Endocrinology. Dr. Kasahara was one of the first to target gene delivery vectors to specific cell types by genetically engineering viral proteins. From 1996-2002, he was on the faculty in the Departments of Pathology and Biochemistry & Molecular Biology and the Institute for Genetic Medicine at the University of Southern California (USC), before being recruited to the University of California, Los Angeles (UCLA) in 2003. Until 2013, in addition to being a tenured Professor at UCLA with joint appointments in the Departments of Medicine and Molecular & Medical Pharmacology, Dr. Kasahara was also Director of the UCLA Vector Core & Shared Resource facility. He currently serves as Associate Medical Director of the Viracor-IBT HLA Laboratory in Los Angeles, and is a member of OneLegacy’s Board of Advisors and Chair of its Histocompatibility Committee. As an expert on gene delivery vector technologies, Dr. Kasahara has authored over 120 research articles and has served two terms as a member of the Scientific Committee on Viral Gene Transfer Vectors for the American Society of Gene & Cell Therapy (ASGCT).

MICHAEL KOSS_crMichael Koss

Dr. Michael N. Koss has been the Medical Director of the MNIT Serology Laboratory (and now its successor, the Viracor/IBT Serology Laboratory) for 4 years. He is Professor of Pathology at the USC School of Medicine, where he is responsible for providing pathology services for both the renal and lung transplant programs, among others. He is an internationally recognized lung pathologist who has co-authored more than 130 peer-reviewed papers and several books, including the Armed Forces Institute of Pathology “Fascicles” (text-atlases) on “Tumors of the Lower Respiratory Tract” and “Non-Neoplastic Disorders of the Lower Respiratory Tract.” He has also co-authored portions of the WHO Classification for Tumors of the Lung. He graduated Columbia College, received his MD degree from Stanford University School of Medicine, and did his postgraduate training in Pathology at the Columbia-Presbyterian Medical Center in New York City. Dr. Koss was chair and then co-chair of the Pulmonary and Mediastinal Pathology Department at the Armed Forces Institute of Pathology (an international reference center for pathology consultations) between 1990 and 2000, before returning to Los Angeles in 2000 to resume his position at USC as Professor of Pathology.

NATHAN LEMP_crNathan Lemp

Nathan Lemp, PhD received his BS in Chemistry from University of California, Berkeley and his PhD in Molecular and Medical Pharmacology from University of California, Los Angeles. He has authored scientific articles and book chapters in the fields of oncology, molecular biology, immunology, and viral gene therapy. In 2011, Dr. Lemp joined the MNIT Immunogenetics Laboratory, where he conducted both clinical testing and basic research and oversaw grant applications for both NIH and private funding. Dr. Lemp is currently a Histcompatibility Director in Training at the Viracor-IBT HLA Laboratory in Los Angeles. His current research interests focus on histocompatibility testing and ex vivo modification of organs for transplantation.

Marek_Nowicki_crMarek Nowicki

Marek J Nowicki, PhD is an internationally recognized expert in persistent viral infections. His scientific career began when he was a research fellow at the Medical Academy in Poland in 1976. Later, at the Department of Microbiology at Christian Albrecht University in Germany, he developed and applied cellular immunology assays to evaluate virus-specific immunity. In the same year that French and American researchers discovered HIV, he was invited to join the liver diseases research team studying HBV and NANB (HCV) infections at Huntington Memorial Hospital in Pasadena. Shortly thereafter, in 1985, he joined the University of Southern California (USC) where he remained as faculty until 2013. His research at USC involved all aspects of transfusion-transmittable infections, immunology of bone marrow rejection and mechanisms of T-cells regulation. For over a decade he has been involved in research of transplant transmitted infections. He is Research Director for Viracor IBT Donor Screening Laboratory and MNITF Director of Transplant Research, in Los Angeles. He is the author of more than 100 publications and presentations at national and international scientific meetings.